TMAU webinar about the potential therapy 'FMO cream'

TMAU webinar June 2015
Hosted by : Rob at rareconnect.org
Guest speaker : Jake Wintermute PhD
Webinar title :  Synthetic Biology and Microbiome Engineering approaches for Trimethylaminuria



My understanding of this subject :
It could leads to a 'FMO cream' that is currently theorized as being based on genetically modified harmless skin organism rich in FMO that would oxidize TMA and other FMO substrates on touch.

The end product could be cheap and easy to manufacture but it may take millions to develop

A funder would need to be found for such a project (probably a pharma company)

As FMO needs oxygen to thrive, currently it is thought it could only realistically be a skin cream and not a 'probiotic' that could be taken orally as the gut is mostly a very 'oxygen deprived' area.

Other speculative thoughts :
Perhaps it would not need to be a 'probiotic' cream but rather just a FMO rich cream or some other oxidizer that is capable of oxidizing FMO3 substrates. FMO3 substrates can be oxidized by other metabolic pathways (not usually in humans).

It would probably not have to be specifically FMO3 enzyme, but merely a FMO enzyme (there are are 6 types of FMO enzymes known : FMO1 - FMO6). FMO's hopefully have a broad overlap in function in this situation.  

The perfect scenario would be some sort of pill that oxidizes FMO3 substrates in the gut.  

It is a very exciting potential therapy. Lets hope we can get the project going.

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By sysbodyodor

crowdfunding, fecal body odor, fmo3, FMO3 research, possible future therapy, systemic body odor, tmau, TMAU research, TMAU skin cream project, video, videos, webinar

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TMAU webinar : Monday 8 June 6pm Paris time

rareconnect.org webinar

Monday 8 June

6pm Paris time

Webinar title :

Synthetic Biology and Microbiome Engineering approaches for Trimethylaminuria (TMAU)

Guest Speaker :

Jake Wintermute, Ph.D.

Postdoctoral Researcher

Paris Descartes University

in the rareconnect.org Webinar Room : click here
to check your local time : google '6pm Paris time'

Jake is a biologist at the Centre de Recherches Interdisciplinaires in Paris. In the summer of 2014, Jake challenged a team of undergraduates to use genetic engineering to improve human health and well being. The result was "The Smell of Us," a collection of new biotechnologies to control body odors by engineering the bacteria that live on human skin. The team's work was awarded prizes for "Best New Application" and "Best Art and Design" in an international genetic engineering competition can be seen online (http://2014.igem.org/Team:Paris_Bettencourt).

In this webinar, Jake will discuss his group's work-in-progress on TMAU. The primary pathology of TMAU is the appearance of trimethylamine (TMA) in the sweat. Many microbes are capable of metabolically neutralizing TMA, including some that occur naturally on human skin. Genetic modification may enhance this ability, creating microbial products to attenuate the symptoms of TMAU. Jake will discuss his scientific progress and the specific challenges of developing a genetically modified organism for human use.

Link : TMAU project for IGEM 2014 

Webinar will be free and recorded

rareconnect.org Webinar Room

My own comment :

This is a realistic potential therapy for 'FMO3 malodor' on the skin. It would be better if it could result in 'internal solutions' such as a probiotic that would oxidize FMO3 substrates before being absorbed into the bloodstream, but because the microbe need an oxygen rich environment they would not survive in the gut. But who knows, maybe one day. So skin products with these microbes is a decent 'bandaid' and supposedly cheap and easy to make. Unfortunately it needs lots of funding to create such a product, as no doubt Jake will explain. It should be a great webinar. Don't miss it (but it will be recorded and put on youtube).

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By sysbodyodor

announcement, join in, media, possible future therapy, tmau, TMAU research, webinar, webinar announcement

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BORC recorded call with London TMAU nutritionist

Body Odor Resource Center

Thanks to Lisa of the Body Odor Resource Center for arranging another great phone conference call for the trimethylaminuria (TMAU) community today.

This time the guest was :
Kit Kaalund Hansen of the Metabolic Kitchen London

You can listen to the call and previous conference calls on the BORC website
listen to BORC recorded conference calls

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By sysbodyodor

media, metabolic malodor patient advocacy, raising awareness, webinar

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BORC Podcast of Dr Robin Lachmann conference

BORC (Body Odor Resource Center) has been arranging a number of conference calls with people that may be of interest to people who have trimethylaminuria (TMAU)

The most recent conference call was with Dr Robin Lachmann of the Charles Dent  Metabolic Unit in London. Dr Lachmann has a few years background in seeing TMAU patients.

A podcast of the conference call can be heard on the BORC podcast website
Dr Robin Lachmann conference call with BORC

BORC youtube channel : link

My view on TMAU
Personally I think people with a problem with their FMO3 enzyme may be prone to smelling of various sulfides and amines that are oxidized by FMO3. This would include trimethylamine but it may be a 'small player' in the number of compounds the person smells of. TMAU came about because the professionals at the time were only looking for trimethylamine. There has been no attempts to look for other compounds. However TMAU is a useful lever to rasie awareness of the concept of metabolic malodors, and trimethylamine should also  be a good biomarker of FMO3 function which I suspect is the main enzyme responsible for most cases of metabolic malodor.

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By sysbodyodor

metabolic malodor patient advocacy, support, tmau, video, webinar, website

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First rareconnect TMAU/FMO3 webinar

The first rareconnect TMAU/FMO3 webinar took place on 21 August. Here are the 2 parts.

Part 1 : Host Rob Pleticha explaining how rareconnect can help the TMAU community
Part 2 (audio) TMAU activist Karen : “Is it possible to use the media effectively in odour sufferers' struggle for human rights”





Webinar post on rareconnect.org site

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By sysbodyodor

fmo3, tmau, webinar, youtube

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