Hosted by : Rob at rareconnect.org
Guest speaker : Jake Wintermute PhD
Webinar title : Synthetic Biology and Microbiome Engineering approaches for Trimethylaminuria
My understanding of this subject :
It could leads to a 'FMO cream' that is currently theorized as being based on genetically modified harmless skin organism rich in FMO that would oxidize TMA and other FMO substrates on touch.
The end product could be cheap and easy to manufacture but it may take millions to develop
A funder would need to be found for such a project (probably a pharma company)
As FMO needs oxygen to thrive, currently it is thought it could only realistically be a skin cream and not a 'probiotic' that could be taken orally as the gut is mostly a very 'oxygen deprived' area.
Perhaps it would not need to be a 'probiotic' cream but rather just a FMO rich cream or some other oxidizer that is capable of oxidizing FMO3 substrates. FMO3 substrates can be oxidized by other metabolic pathways (not usually in humans).
It would probably not have to be specifically FMO3 enzyme, but merely a FMO enzyme (there are are 6 types of FMO enzymes known : FMO1 - FMO6). FMO's hopefully have a broad overlap in function in this situation.
The perfect scenario would be some sort of pill that oxidizes FMO3 substrates in the gut.
It is a very exciting potential therapy. Lets hope we can get the project going.
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