News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

5 April 2016

TMAO Research China : Resveratrol inhibits trimethylamine

Chinese Research April 2016.
Resveratrol inhibits TMA-producing bacteria and helps friendly bacteria.
This in theory should help with trimethylaminuria (TMAU).
But be wary.

About :
A new research paper saying that resveratrol inhibited TMA-producing bacteria growth in mice gut (?). Since Hazen et al at Cleveland in 2011 put forward a theory that TMA-oxide may be a factor in atherosclerosis, researchers will now be looking at ways to stop TMA production in the human gut. This Chinese lab seems to be about how natural nutrients may play a role in human health. In this case they checked the effect of resveratrol on TMA and TMAO production in the gut.

Their conclusion :
Glancing at the abstract and news releases this is my first impression of what they say.
Resveratrol inhibits TMA producing bacteria.
Some say it favors bacteriodes over firmicutes.
They say it favors the lactobacillus and bifidus family (good species).

Links :
Resveratrol TMAO paper in news : Eureka Alert
Medical News Today
Abstract in mBIO medical journal interview

My comment on this paper :
Resveratrol is a polyphenolic compound naturally found in peanuts, grapes, red wine, and some berries.
Linus Pauling Inst.
Papers come out all the time saying one thing then another contradicts is. So I wouldn't give this paper much weight at the moment. But it puts the spotlight on resveratrol as a possible use for TMAU therapy. They are probably looking at compounds high in the Mediterranean diet that might explain their supposed healthy heart role.

What has this to do with systemic body odor ?
Acronynms :
TMA - trimethylamine
TMAO - trimethylamine oxide
TMAU - trimethylaminuria
CVD - cardiovascular disease
SBO - systemic body odor
My own view is that FMO3 substrates may make up about 95% of cases of 'systemic/metabolic body odor'. However, at the moment only the substrate TMA is documented as being a 'systemic body odor' cause. So for SBO, everything currently revolves around TMA. Since 2011, a theory was put forward that TMA-oxide may cause CVD, which ironically was good news for those with TMAU as it will likely mean a therapy to reduce/inhibit TMA.

My final comment :
It's an interesting read but like I say it should be taken as 1 paper from a lab that focuses on natural nurtients for a living. I don't know if the TMAU community have been trying resveratrol already. I don't follow diet/supplement discussions closely. But I suppose resveratrol is another to talk about.

The best news is that there is probably 'TMA-inhibition' research going on around the world that we don't know of.

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TMA blocker pill (links)

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FMO3 DNA testing
Update Aug 17 :
Genos is back with it's EXOME test

Note :
Exome/Genome testing may be better option than single gene testing.

See this post : link

Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.

Does Genos fully sequence FMO3 gene ?

At the moment it is not clear, but hoped this will become clear over the next few months

Note : possible 'wild west' way of testing FMO3
Use an ancestry dna site and rummage through the raw data

TMAU Webinar #5 : Preti et al