News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

Systemic Body Odor : QUICK REFERENCES

I will use this page to note down quick references to points I think may be relevant to systemic body odor.
Last updated : Nov2016.
note : info may not be totally correct. do your own research.

Quick references about systemic body odor

Acronyms :

TMA : trimethylamine.
TMAU : trimethylaminuria

TMA and microbes :

Bacteriodetes tend to NOT produce TMA
Firmicutes tend to produce TMA.
Methanogens (e.g. archea) can break TMA down to methane and acetaldyhyde

Possible ways to inhibit/breakdown TMA :

1. microbe methane pathway. Some microbes breakdown TMA to methane and acetaldehyde. Probably 'methanogens'.
2. microbe enzyme blocker. Many antibiotics work this way. They block a microbe enzyme so as not to produce something. In this case blocking formation of TMA.
3. 'fool the microbes with an imposter'. Another known option is to mimic choline with an imposter that is harder for the microbes to break down to TMA. This seems to be the Cleveland Clinic research goal.

Known TMAU therapies or research  :

Proctor and Gamble working on a 'choline imposter' to fool the microbes. Announced deal in Aug2015. Will be over-the-counter supplement.
Expected release date : Unknown. Could be years.  


re Email sub service : Google is stopping this service JULY 21 new post emails will no longer happen

TMAU Stories

systemic BO/halitosis important links

MEBO Research malodor study 2016


FMO3 reference

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TMAU/FMO3 research

Systemic Body Odor links

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Do you have systemic body odor ?

FMO3 Survey Form

FMO3 DNA test result survey
for those who have FMO3 DNA tested
survey still OPEN

TMA blocker pill (links)

P&G - Cleveland press release aug 2015
1st mention of 'DMB pill' dec 2015
FMO3 DNA testing
Update Aug 17 :
Genos is back with it's EXOME test

Note :
Exome/Genome testing may be better option than single gene testing.

See this post : link

Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.

Does Genos fully sequence FMO3 gene ?

At the moment it is not clear, but hoped this will become clear over the next few months

Note : possible 'wild west' way of testing FMO3
Use an ancestry dna site and rummage through the raw data

TMAU Webinar #5 : Preti et al