By A Finnish group, probably with help by the Cleveland Clinic team.
My context for the study :
Currently of limited interest to me.
Posted moreso that others can read it thorough if they wish.
I am skeptical about the microbes listed as being associated with TMA production.
The Study (in terms of TMAU interest) :
531 Finnish men had their gut flora DNA tested to 16S standard.
Presumably they had a connection with CVD.
Since TMAO will probably require therapies to lower TMA levels, it will very likely mean therapies for TMAU.
Since the theory is TMA-oxide is associated with CVD, they looked at microbes that may be associated with high TMAO levels.
The microbes they associate with TMA-oxide
Peptococcaceae
Prevotella
unknown Clostridales
Peptococcaceae
Prevotella
unknown Clostridales
Looking at my Ubiome results, which are 16s standard testing :
I had :
Peptococcacae : none.
Prevotella : about 0.18%.
Understanding of gut flora :
I view the knowledge of the gut flora as at the very early stages. A bit like before America discovered.
Final thoughts on the study :
I believe TMA is only a biomarker of FMO3 function, and a small player in the range of FMO3 volatiles someone with a FMO3 isssue may smell of.
So I am sceptical that a therapy that may only reduce TMA in humans will solve what I regard the most common type of systemic/metabolic body odor (FMO3 substrates body odor). BUT HOPEFULLY I AM WRONG.
But it may be that reducing TMA levels reduces the load greatly on FMO3 to levels where the enzyme can handle all smelly substrates.
Back to this study, it's great so much research is going into understanding TMA metabolism in humans, and for sure it will result in 'TMA therapies' as they are associating it with heart disease. So we can expect many more studies like this, and much greater understanding of TMA metabolism in humans.
Compare this to pre-2011, where we were lucky to get a TMA paper every 5 years.
Paper :
Relationships between gut microbiota, plasma metabolites, and metabolic syndrome traits in the METSIM cohort : Link
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