TMA-oxide and Chronic Kidney Disease

Since the hypothesis around 2011 by Dr Stanley Hazen et al at the Cleveland Clinic that TMA-oxide may be a cause or good biomarker of Chronic Vascular disease there has been interest in TMA-oxide and it's metabolism (TMA, FMO3 etc). Before this the FMO3 enzyme and TMA/TMAO was largely ignored. Now research papers investigating TMA-oxide in particular can be anything between 1-5 a week.

So far I have seen papers suggesting TMAO may be linked to (as I recall) :
CVD
Inflammatory bowel disease
Chronic Kidney Disease  

Whether it will turn out there is a connection is another thing.

What has this to do with metabolic/systemic maloldor ?
My current opinion is that the most likely cause of most cases of metabolic malodor is to do with FMO3 enzyme substrates, trimethylamine being one. FMO3 was largely ignored by medical science until the proposed TMA-oxide/CVD connection in 2011. So all this research into checking if there may be a connection to major health disorders is very welcome as it may lead to more understanding of FMO3 and perhaps therapies.    

These 2 new published papers are about a possible TMA-oxide and Chronic Kidney Disease connection. It seems to imply those with CKD and CVD may have higher TMA-oxide levels ?

The main paper is by the Kidney Institute in Kansas
Serum Trimethylamine-N-Oxide is Elevated in CKD and Correlates with Coronary Atherosclerosis Burden :link

The other paper is by the Genomics Center at Cleveland Clinic
Trimethylamine N-Oxide as a Novel Therapeutic Target in CKD : link
http://www.ncbi.nlm.nih.gov/pubmed/26229138

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By sysbodyodor

fmo3, Hazen TMAO research, TMAO Research, TMAO-CVD

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