media article on TMA-oxide reduction
ohio.com, December 2015
About Dr Hazen et al announcement in Dec 2015 that DMB seems to reduce TMA-oxide in mice
Link
Quote from the article :
The most recent discovery builds on the research team’s initial 2011 revelation that a biomarker called TMAO could predict heart disease independent of cholesterol levels and other risk factors. TMAO can also ferret out the disease in those whose heart disease might otherwise go undetected.
TMAO is produced during the digestion of choline, lecithin and carnitine, nutrients that are abundant in animal products, including red meat, egg yolks and high-fat dairy products.
People with chronic high levels of TMAO have double the risk of heart attack, stroke and death.
During an interview this week, Hazen said his team started searching for an inhibitor, a substance that could prevent TMAO from forming and, thus, perhaps stop heart disease.
In the beginning, they engineered a compound in a lab that worked to reduce TMAO production by gut microbes. But the synthetic compound was essentially what chemists refer to as a “small alcohol,” and they wondered if it might exist as a natural product.
“We literally put together take-home gift bags of vials and labels for the staff,” Hazen said. “We asked them to take samples of every alcohol in their pantry … vinegars, oils, distilled products.”
Researchers screened thousands of the samples. They found what they were looking for — DMB, a chemical which looks like the nutrient choline, but interferes with the production of TMAO — in some cold-pressed extra-virgin olive and grape seed oils.
So what does this mean for consumers?
Not much, yet.
The research team has only tested the TMAO inhibitor DMB on mice, so far. But the mice treated with DMB were fed the equivalent of a diet rich in red meat and fatty dairy and developed less atherosclerosis.
Hazen hopes doctors can someday use DMB to control TMAO much like doctors uses statins now to inhibit cholesterol.
The most recent discovery builds on the research team’s initial 2011 revelation that a biomarker called TMAO could predict heart disease independent of cholesterol levels and other risk factors. TMAO can also ferret out the disease in those whose heart disease might otherwise go undetected.
TMAO is produced during the digestion of choline, lecithin and carnitine, nutrients that are abundant in animal products, including red meat, egg yolks and high-fat dairy products.
People with chronic high levels of TMAO have double the risk of heart attack, stroke and death.
During an interview this week, Hazen said his team started searching for an inhibitor, a substance that could prevent TMAO from forming and, thus, perhaps stop heart disease.
In the beginning, they engineered a compound in a lab that worked to reduce TMAO production by gut microbes. But the synthetic compound was essentially what chemists refer to as a “small alcohol,” and they wondered if it might exist as a natural product.
“We literally put together take-home gift bags of vials and labels for the staff,” Hazen said. “We asked them to take samples of every alcohol in their pantry … vinegars, oils, distilled products.”
Researchers screened thousands of the samples. They found what they were looking for — DMB, a chemical which looks like the nutrient choline, but interferes with the production of TMAO — in some cold-pressed extra-virgin olive and grape seed oils.
So what does this mean for consumers?
Not much, yet.
The research team has only tested the TMAO inhibitor DMB on mice, so far. But the mice treated with DMB were fed the equivalent of a diet rich in red meat and fatty dairy and developed less atherosclerosis.
Hazen hopes doctors can someday use DMB to control TMAO much like doctors uses statins now to inhibit cholesterol.
my own comments on the article :
If you think trimethylamine is the sole compound that causes your malodor, then this would seem like a therapy that in practice may be a cure. It's a question of waiting for the product being ready to buy (can't say how long that is. Could be a year - 5 years, hopefully the sooner)
Personally I think people with an FMO3 enzyme issue may have malodors from any FMO substrates in humans, which are small sulfides and amine. So I am not sure something that just deals with TMA alone will be enough. But hopefully I'm wrong.
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6 comments:
I have tmau type 1. When I'm on antibiotics it reduces the smell about 95% but after 6 weeks the smell returns so my question is if antibiotics work for you will this work too?
It seems it will stop the bacteria breaking choline down to TMA, so I think it should stop or at least reduce TMA formation in the gut. So it should work in a similar way, but since it's natural and probably harmless, you will probably be able to take it all the time.
So TMA is what makes us smell not the choline? Bit confused on this.
TMA makes people
I think what happens :
Bacteria breaks choline down to TMA
DMB is similar to choline in structure
The bacteria tries to use the DMB but it's not as good
This causes that bacteria to die-off
Something like that, but I'm not sure.
Thanks for the reply. Let's just hope and pray whatever they produce works for all of us.
I'm sure it will work on TMA to some degree. Not sure how much. Hopefully 100%. I seem to be wrong about it killing bacteria. But it does seem to reduce TMA formation in the gut. I'm pretty confident it will do that, as it's for the 'Heart Disease' market.
My main concern is that TMA may be only 1 of many volatiles that make me smell, and even then might be a small player. But we will see. It's hopeful news.
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