FMO3 has been taught that it cannot be induced as most other redox enzymes can (e.g. the CYPs).Perhaps this thinking is because so few have investigated FMO3.
A recent paper suggested a Korean herbal mushroom may induce FMO3.
DRUG REPURPOSING :
A (new ?) method of (relatively) 'inexpensive' enzyme research is to check how drugs past their patent period to see if they may be of any use in other health conditions.
Drug Repurposing for enzyme disorders (e.g. FMO3)
For enzyme disorders this probably involves checking the reaction of the enzyme to a list of unpatented drugs in a lab (e..g FMO3). In this case a priority would probably to be to see if it can INDUCE FMO3 (i.e. make it work harder) so you maybe get another 10-20% output.
Main benefits of Drug Repurposing (?) :
It's RELATIVELY inexpensive.
It should be reasonably quick and easy to do (? a year ?)
A lot will be known of the drugs already.
May learn more about enzyme (e.g. a group of compounds induce/inhibit)
RESEARCHER INTERESTED IN FMO3 DRUG REPURPOSING
A researcher has shown an interest in putting FMO3 through the 'drug repurposing' check.
As usual funding would be the issue.
A opening estimate is that it may cost around $US 74,000 (probably mostly to hire someone to run the checks.)
An opening estimate is that it would take around a year.
They are looking at possible ways of getting funding but it's difficult.
It's something the community can think about.
A researcher has shown an interest in putting FMO3 through the 'drug repurposing' check.
As usual funding would be the issue.
A opening estimate is that it may cost around $US 74,000 (probably mostly to hire someone to run the checks.)
An opening estimate is that it would take around a year.
They are looking at possible ways of getting funding but it's difficult.
It's something the community can think about.
Links about Drug Repurposing :
NIH USA website
wikipedia
101 website
findacure UK
FMO3 and Systemic Malodor
My own interest in FMO3 is because I currently suspect it is my main suspect enzyme for most cases of 'systemic/metabolic malodor' (i.e. caused by an enzyme deficiency or overload, not hygiene etc).
FMO3 oxidizes many sulfides and amines in humans. But other enzymes cannot be ruled out.
Current possible therapies for TMAU or FMO3 'smells' :
TMA inhibition/reduction in the gut (e.g. Cleveleand Clinic working on a reducer to be marketed as a supplement by P&G. Not known when it will be available).
TMA metabolization in the gut (e.g. 'probiotic' that metabolizes TMA. Probably a 'methanogen' which will take it the methane route.)
'Gene Therapy' (probably ideal option)
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2 comments:
What about Ataluren, a new drug for overriding nonsense mutations, that holds promise for TMAU sufferers? Made in America, it has been approved in the European Union but not in the USA. The FDA is refusing to consider it for now.
But if in the near future, the FDA did approve of Ataluren, would this research on discontinued drugs to boost FMO 3 even be necessary?
A Google search on Ataluren, or Ataluren approval in Europe, brings up all the information on this topic.
I think the researcher plans to use ataluren as a 2nd part of his research. ataluren only works for 'premature stops', which is 'nonsense' mutations. It will negate the 'false stop'. Only about 10% of tmau1 cases have nonsense mutations. It's a very severe type. So for most tmau1 cases it will have no effect. But hopefully it would help those who do.
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