News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

Showing posts with label malodor sensor. Show all posts
Showing posts with label malodor sensor. Show all posts

11 December 2016

AIRE Breath Sensor for FODMAP

Foodsniffer (not the AIRE)
A start-up called FOODMARBLE is launching a breath sensor.
Called the AIRE Breath Sensor.
It is designed for the FODMAP diet.
Detects : HYDROGEN levels ?
Hydrogen is thought to be the main gas given off during gut fermentation.
Hydrogen is used as the gas tested for 'small intestine bacterial overgrowth'.

Possible interest to those with systemic body odor/halitosis :
The blog current view is that FMO3 enzyme may be the weakness for most type of SYSTEMIC BODY ODOR (SBO).
Many of the gases from gut fermentation are probably FMO3 substrates (e.g. certain sulfides/amines).
Many with 'fecal body odor' feel they have 'gut dysbiosis'.
Something like the AIRE may help them track their 'dysbiosis' via hydrogen level.



Initial thoughts about the AIRE :
It's version 1. With hindsight it may be regarded as not very good.
BUT, people with SBO will for the foreseeable future need 'sensors' (probably breath sensors).
If it worked, it may be of some use to track 'gut dysbiosis'.
The platform (device for phone, bluetooth etc) is ideal for the consumer. A SBO sensor will be probably the same (but detect different gases e.g. dimethylsulfide).
Great price ($99 intro price). At that price it's worth a gamble.
(note : I already bought the 'foodsniffer' and 'mint breathometer' (not arrived after 2 months), so will probably not be buying the AIRE soon).

AIRE Sensor website
Twitter
Daily Mail (dec 16)
Press Release (dec 16)
Business Insider (may 16)

Systemic Body Odor needs a Consumer Sensor :
SBO will need it's own version(s) of a 'sensor'. Once it's known what gases act as biomarkers or to detect all the types of gases that cause SBO. A good 'suspect' would be 'dimethylsulfide'.
Currently such a sensor does not exist for systemic body odor.
Partly as the technology had not reached a decent level yet.
Also it seems sensor makers are only realising there was a consumer market for say 'halitosis' sensors, or hydrogen sensors. More because of start-ups getting in the market via crowdfunding.
with SBO, the person usually cannot smell themselves (my opinion, they are usually transient and the brain ignores it's own circulating smells).

One thing is for sure, SBO will need a sensor that detects SBO gases.
Currently we do not know what these gases are (apart from trimethylamine).
It's likely sulfides like dimethylsulfide will be suspects.

Fecal Body Odor :
Probably it's unknown exactly what gases make fecal smells.
Scientists will have a good idea of suspects, but papers are few and contradictory.
Perhaps for SBO, there may be a wide spectrum of sulfides/amines at any point, but perhaps a handful of 'big players' (e.g. dimethylsulfide) which could then act as 'biomarkers' for a sensor.

Possible 'big players' for Fecal Body Odor (guesses) : 
dimethylsulfide
dimethyldisulfide
methanethiol
cysteamine

FINAL THOUGHTS
The SBO community will need their own 'sensor' as they are 'nose blind' to their own smells.
The tech (and makers will) has not been there for consumer sensors.
But over the last 2 years, both the tech and now we see the will, for consumer sensors is happening.
No sensor maker would currently probably invest in a 'SBO sensor', thinking there is no market.
But other sensors may longterm make the process cheaper.
Many with SBO feel they have 'gut dysbiosis', so a sensor like the AIRE may be worth a gamble.
Keep in mind for AIRE it's version 1 (i.e. early days).  

What SBO needs
1. To find out all (or at least the main) volatiles that cause SBO (exploratory tests).
2. From that info, a diagnostic test.
3. A Sensor(s)
4. A DNA test (probably being superceded by exome/genome tests which are mathing price of single gene tests).
5. Therapies/cures.


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17 September 2016

Mint Breathometer ... to detect stinky breath

Mint Breathometer app and device to detect halitosis.
Available in USA from 30th Sept 2016 (can pre-order now).
$100.

The systemic/metabolic body/breath malodor community usually cannot smell themselves when they smell, so I have thought a phone based 'odorometer' is as essential as therapies and 'clinical' tests. I have looked around for leads and found no company to view it is likely profitable. This was frustrating as I figure the 'bad-breath vanity' market for say 'halitophobia' would be as big as mouthwash, and quite often they may check for some 'volatiles' that may be common to the main type of  systemic body odor (e.g. mercaptans, hydrogen sulfide etc).

It was inevitable that phone breathometers would come along, although this 'version 1' breathometer seems the first one and only one available. Perhaps it has also taken the technology up until now to catch up with the concept, and even now it's probably pretty new and probably subject to many changes until the tech matures.

links :
Breathometer site
Indiegogo : where Mint breathometer started
Mint Breathometer article in Techcrunch
article in Venturebeat (9/16)

Charles Yin is the 'tech entrepreuer' who owns the company. So far he found riches in 2 tech companies (selling them. Not sure if they are still around). Now he doesn't need money.

He appeared on 'Shark Tank' looking for funding for a 'phone alcohol breath sensor', which all 5 sharks gave money for (a bit worrying imho. I would want the publicity but not their stake). A 'breath alcohol phone sensor' sounds not very interesting to me, as there are so many small breathylyzers around.

It seems now they have dumped the 'alcohol breathalyser' and are focusing on detecting all kinds of volatiles that may be related to health. And as I say, the halitophobia vanity market is probably huge and this seems their current focus.

Philips
It seems that Philips are now involved, meaning the tech will have unlimited funding/research, and this means it's probably a long-term part of their oral healthcare strategy.

Relevance to Systemic Body Odor
My own feeling is that those with SBO tend to emit the volatiles through every part of our body, and the breath is probably a good indicator. Some feel they have Systemic Malodors only through their breath. Personally I feel my main problem is SBO, but even then there may be a higher than normal amount of volatiles in my breath when smelling.

The SBO community needs a sensor device as much as therapies, clinical tests etc, and currently this seems the nearest to the aim of a portable sensor for SBO. It looks like it tests for the common VSCs they look for in 'traditional localized halitosis'. I am sure one or more of these will be common in SBO (suspects like sulfides).
And at the moment this is really the only sensor on offer.

Foodsniffer
This device became available about 2 years ago. Again starting on indiegogo (possibly to test the market) then going 'professional'. This is meant to tell you if food is spoilt, about to spoil, or fine. I bought one and it does seem to sense something (e.g. I tried over a bin). It was also pretty good tech overall imho (bluetooth, nice app, well made device).
But I have little to no confidence in it to monitor SBO (as it wasn't intended to).

Mint Breathometer worth buying for SBO ?
For SBO, I would put this down as an 'exploratory gamble buy' that may obviously not be useful after a day or 2 (for SBO monitoring). But currently we have no choice so I'm thinking it's better than nothing.
It's on the right trajectory for SBO, but not quite designed for SBO. Personally I think the 'SBO' market itself will be huge (my estimate, 1% population 'at risk', or would at least buy a sensor). The 'halitophobia' market will be even bigger. I would guess almost everyone worries about halitosis.            

         

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Update Aug 17 :
Genos is back with it's EXOME test
link

Note :
Exome/Genome testing may be better option than single gene testing.

See this post : link

Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.


Does Genos fully sequence FMO3 gene ?

At the moment it is not clear, but hoped this will become clear over the next few months

Note : possible 'wild west' way of testing FMO3
Use an ancestry dna site and rummage through the raw data

TMAU Webinar #5 : Preti et al