FMO3 mutation successfully replaced by a normal copy in a single cell mouse embryo
They think it will 'cure' the mouse and each future generation
This is stage 1 (proof of concept), so probably would take years to reach a clinical therapy if that were possible
Probably the 1st time this has been tried with FMO3
A commenter tells me this is unlikely to lead to a therapy for anyone other than embryos
Link (pubmed abstract) : FMO3 gene therapy in single cell mouse embryo : China
comment :
A group of Chinese academics seem to have for some reason tried to change a mutated FMO3 gene in a mouse embryo and change it to a 'correct' FMO3 gene using gene therapy. It seems they were successful. Why they chose FMO3 is not known.
Keep expectations in context :
While it's exciting to see the concept of gene therapy for FMO3 in a mammal proven, an expert has suggested to me it is not likely to result in a therapy for humans other than those at the embryo stage.
Still, it's an interesting development. It would be interesting know why they chose FMO3 as the gene to try, and if they plan to continue this research using FMO3.
Why FMO3 is of interest to systemic body odor :
It is my belief that FMO3 gene is responsible for what is commonly referred to as 'Fecal Body Odor', which I think is due to the build up of FMO3 substrates. FMO3 oxidizes many sulfides and amines.
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