The TMAO-Generating Enzyme Flavin Monooxygenase 3 Is a Central Regulator of Cholesterol Balance
Warrier et al, Various USA research labs
Link to abstract of paper : Pubmed
Post about :
New research linking cholesterol metabolism with FMO3 enzyme. This is the 1st time this has been suggested.
Connection with systemic body odor :
It is my suspicion that FMO3 substrates cause most cases of 'systemic body odor' (the common type known as plain 'fecal body odor'). So any research into FMO3 will be welcome, as currently it is generally an ignored enzyme.
My view on this new paper :
Regular readers will be aware that Dr Stan Hazen at the Cleveland Clinic is the lead researcher in a new theory that trimethylamine-oxide (TMAO) may be closely associated with atherosclerosis (CVD). This would be of interest to people with trimethylaminuria (TMAU) as it may lead to research to neutralize trimethylamine in humans. However it would still have left people with FMO3 deficiency of some sort with this deficiency. As I suspect FMO3 substrates other than trimethylamine may cause most of the malodors in 'fecal body odor' syndrome (e.g, sulfides) then neutralising trimethylamine may not have resulted in no more malodor.
Dr Hazen is now connected with thus new paper that suggests FMO3 enzyme has a role in cholesterol metabolism. Dr Hazen is not the lead researcher though the Cleveland Clinic is heavily involved, as are other top USA research labs to do with heart disease.
This new news that FMO3 may be linked to cholesterol metabolism is likely to lead to much research into FMO3 enzyme, which now means that both trimethylamine and FMO3 will now get a lot of research attention. So in my opinion this is very good news for those with systemic body odor especially if it is to do with FMO3 enzyme.
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2 comments:
Wow very interesting research! I for one have high blood pressure and unmediated high cholesterol that cannot be managed with diet. Wish this research started twenty years ago as i think it might take at least that long to come up with any real treatment.
I have only read the abstract of the paper but it may be that people with FMO3 deficiency tend to have lower cholesterol rather than high. I don't know yet.
In a research sense it would be better if low FMO3 meant high cholesterol as then they would look for ways to improve FMO3 function.
Whatever, at least it should generate a lot of interest in FMO3 and the other FMOs
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