Aim : To show differences in trends between OLD test (Nigel's pre-2017 test)
and the NEW post-2016 test.
Measurement is umol/mmol creatinine.
Conclusions :
1. TMA is 10-80 times lower for NEW test ??
TRIMETHYLAMINE levels seems to be 10 to nearly 100 times less than the old test, even though they both use GAS CHROMATOGRAPHY as the method.
The reason given so far is that the old test had 'false positives', which means many were told they were positive wrongly.
For whatever reason, the old test was more in line with numbers I would expect to be positive. My suspicion is the new test spots only GENETICALLY SEVERE TMAU cases now, whereas the bulk of us were GENETICALLY MILD or even borderline or 'carriers'.
Paper of concept 1999 : susceptibility of heterozygotes
2.
There's 5 NEW tests in the survey of 22 (viable answers). So apart from the TMA difference trend, it's hard to make other conclusions.
TMAO levels seem similar but slightly lower. Does not have the huge variance where the OLD test had TMAO levels in the 100's. It looks like none will be over 100 in NEW test.
The 2 above comments are to do with the MACHINE METHOD ; not the 2nd part, the reference range.
SHEFFIELD TMAU Survey :
Anyone can take part in the survey if their TMAU urine test was done at SHEFFIELD CHILDRENS HOSPITAL.
This would be anyone who has tested on the NHS.
AIM : To show difference in patterns of OLD and NEW TMAU test.
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