Probably leading world experts on FMO3 and TMAU.
Overview paper probably contains no new info.
Perhaps Fennema is a student of theirs and did the paper as coursework.
Mentions the TMAO - CVD theory but downplays the connection.
Prof Phillips and Shephard (husband and wife) of London have long been experts in FMO3 and TMAU. They have published many papers on the subject, most probably overviews rather than new research. Fennema is a new name in the TMAU world. Perhaps they are a student of theirs, doing the paper as coursework.
CVD - TMAO theory :
One new issue they write about is the CVD - TMAO theory which was first put forward in 2011 by Hazen et al. My reading of their interpretation is that they are sceptical, and think that TMAO levels may be more a biomarker of general dysbiosis related to obesity, rather than TMAO being the cause of CVD.
Gut flora composition (Bacteroides produce less TMA) :
They also mention that 1 or 2 papers may associate TMA levels with the Firmicute group, and Bacteroide group don't tend to produce TMA as much. At the moment my impression is so little is known of the gut flora that I don't take anything as agreed beyond doubt yet. So it's not something I pay much attention to currently.
Final thoughts :
New TMAU / FMO3 papers are always welcome, and it's a decent overview, but doesn't really add anything new. I'm guessing Fennema is unlikely to publish new TMAU papers if they are a student (except during coursework).
Acronyms :
CVD : cardiovascular disease
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