A general overview of the genetics of FMO3 enzyme.
I think by a member of the public.
Below is an embed of the video.
If the original is deleted this copy will auto-delete.
My comments :
The person has done a good job. I agree with the terminology they use. I think it probably best to discuss FMO3 mutations/variants in that terminology (e.g. E158K, E308G etc)
FMO3 enzyme is a 532 amino acid coding sequence
Think of it as a train track or ladder. You need both sides to make up the amino acid.
Each 'rung' is called a codon
So FMO3 gene has 532 codons (coding sequence)
I agree with what is said in the video, but I would go further and say some' carriers' are probably 'transient sympotmatics' too. In fact I think most probably fit this category.
What I am saying is, at the moment the consensus is that there are sufferers and carriers. I'm saying that some carriers will in fact be sufferers, and the genetic spectrum will go from 'severe' to 'mild' much further than experts currently suggest. This would drag maybe more into the 'danger zone' at times.
For example, e158k and e308g are very common variants, thought to be harmless. I reckon perhaps in tandem with other variants, or in homozygous form (e.g. e158k / e158k), the person may at times fall into the 'danger zone'. Also many will be 'compound heterozygotes'.
Link : my list of FMO3 532 coding sequence
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