E158K is a very common variant in caucasians. Perhaps as many as 40% carry a copy. It is at codon 158 of the 532 FMO3 coding sequence. Normal would be EE. But many are EK (carrier). The current (lack of) evidence is that those who are EK or even KK at 158 should still have a fully functioning FMO3 enzyme. But I am sceptical of this.
Link to Pubmed abstract : E158K and heart disease in women
Context of paper :
This paper suggests that females with KK at 158 are strongly associated with chronic heart disease. This is the first time I have read this. Since 2011, there has been a hypothesis that TMA-oxide is associated with CVD (and now possibly other diseases), but this is the first time I have seen this specific connection with 158 variant KK. The TMAO-CVD connection is still being debated by health researchers, and now this new paper will likely be of new interest but for now needs to be seen as a sole paper.
The homozygous 158KK genotype of FMO3 gene is associated with high risk of chronic heart disease in women, but not in men. FMO3 gene polymorphism E158K is a significant predictor of predisposition to chronic heart disease in women.
What has this to do with systemic body odor (SBO) ?I suspect that the most common cause of SBO is deficiency and/or overload of the FMO3 enzyme. This will lead to smells of sulfides and amines. I suspect in most cases it is a combo of deficiency and overload. So any research to do with FMO3 is of interest. Before the 2011 paper there was almost no interest in FMO3 research/understanding. Now because of this proposed CVD connection, there is a lot of interest.
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