Metabolic retroconversion of trimethylamine N-oxide and the gut microbiota.
Reading Uni UK.
About :
How some gut bacteria can break down TMAO back to TMA.
Full paper : Link
Significance to TMAU :
Probably not that significant as most gut TMAO in humans would likely be from eating fish. Fresh fish contain a lot of TMAO.
Not unless the TMAO comes back from the blood into the bowel.
This would be known as TMAO reduction (to TMA).
Probably not the same as cleaving TMA from choline etc.
Main reason for posting the paper is bits and pieces of mild interest.
Not read the paper proper so the points below may be inaccurate.
Possible interesting points re TMAU
It says :
Enterobacteriaceae are the main TMAO reducers ?
Most of the TMA creation was around the lower small intestine and cecum, not the colon ?
Most of the TMA is absorbed, very little in feces ?
Not really much connection with TMAU but good to know research is going on about the gut flora and TMA metabolism.
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