new TMAO blood test at Cleveland Heartlab

Since December, Cleveland Clinic has started it's TMA-oxide blood test via the Cleveland Heartlab. As regular readers will know, since 2011 Dr Hazen et al at the Heartlab have suggested that TMA-oxide may be an important factor in causing heart disease. This is what is leading them to look for ways to reduce trimethylamine levels in the gut.

Link : Cleveland Heartlab TMAO test

What has this to do with systemic body odor ?
Trimethylaminuria (TMAU) is currently the only documented type of 'benign' systemic body odor. Since the probable therapy to reduce tma-oxide levels in the human gut will be to reduce TMA levels, then those who feel TMA is their only source of malodor are likely to benefit from any 'TMA reducing' therapy that is created for heart disease. At the moment it looks like DMB will be sold by Procter & Gamble sometime in the future as it has been shown to reduce TMA levels in mice.

My own view :
I think most people with systemic body odor smell of any FMO3 substrates that happen to be too high in their body at any time. This means many small sulfides and amines that are created in humans, particularly in the gut. So whilst I am very interested in a 'TMA reducing' therapy, I do worry that TMA may not be the only compound that causes malodor in 'FMO3 maldoor syndrome'. But the eventual release of the DMB compound for sale is something to look forward to.  

DMB : 3,3-Dimethyl-1-butanol   
Wikipedia

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By sysbodyodor

Hazen TMAO research, TMAO Research, TMAO-CVD

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