A new paper by the Cleveland Clinic to do with Heart Failure and TMAO.
Posted here as any research on TMA-oxide may have a benefit for TMAU.
Abstract implies they are researching the human gut microbiome, probably mostly to learn more about trimethylamine metabolism in humans.
link pubmed abstract
My perception of the paper from reading the abstract :
Looks like another paper by the Cleveland Clinic Heartlab. Tang is usually involved in these papers. This one looks to be perhaps an overview of what is known about the human gut microbiome and what they know of trimethylamine formation in the gut (not much, it seems to me). I'm guessing it's a sort of 'starting paper' for as they go on to research more on the microbiome. Interesting to see them use the term 'dysbiosis', which is a term I often use. This seems to be the 'DNA' exploration side of their 'TMAO - CVD' theory. In this case probably exploring the gut microbe DNA, rather than human DNA such as FMO3. Should be relevant for TMAU as well.
My view :
It's good to see this lab producing so many papers on the subject. It will likely help us understand TMA metabolism in humans, which should help with TMAU. As many will know, they already have a TMA formation interfering compound in the pipeline ... DMB.
What is this to do with systemic body odor / halitosis ?
Personally I think most who complain of 'fecal body odor' actually have 'FMO3 substrate body odor', with TMA being only one substrate. For that reason I am not overly excited about this reasearch if it only stops TMA. But at the same time it may turn out to greatly help with 'FMO3 body odor' or it is a start to understanding FMO3 and gut dysbiosis, or I might even be wrong and TMA is solely to blame for 'fecal body odor'.
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