News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

7 December 2014

New TMAU paper : Archaea neutralise TMA in the gut

About : New paper that says that archaea microbes neutralise trimethylamine in the gut. In future perhaps 'archaeabiotic' treatment will help people with TMAU and perhaps do away with the need for diet control etc.

This is a paper about the possible role of archaea microbes in neutralising trimethylamine in the gut. Archaea are methane producing organisms common in many people guts but not all. In the microbe breath test, some people are shown to be methane producers as well as hydrogen producers, whereas some are just hydrogen producers. It seems that archaea produce this methane.

The paper says that perhaps in the future people with TMAU may be able to use an 'archaebiotic' to in effect 'neutralise' trimethylamine in the gut. This would be in practice a 'cure' for TMAU, but anyone with a FMO3 deficiency would still have that deficiency.

Full paper : Archaea and the human gut: New beginning of an old story Link to full paper

My view on this :
This is very good news. If something can neutralise TMA in the gut then there is no TMA going to the liver. It neutralises the TMA load. However the person still has an FMO3 deficiency if they are TMAU1. For those who feel they only smell of trimethylamine, it is in effect a working cure I guess. However FMO3 oxidizes many sulfides and amines in humans, and I believe that most people with an FMO3 issue smell of other sulfides and amines mostly, and it would not seem to be a cure for that. Not unless it also neutralises those volatiles too.

Overall though it is a very positive step and the 'archaeabiotic' would be a natural solution rather than taking a drug.  



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Note : Genos Exome Testing.

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