News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

5 December 2014

Female hormone estradiol shown to inhibit FMO3

Post about : Italian researchers proving that the main female sex hormone,  17β-Estradiol, does inhibit FMO3 levels 'in vitro' human DNA/RNA testing.

In 2007 a paper was published where adult females who menstruate who have a TMAU diagnosis were TMAU tested daily over 120 days to check their TMA/TMAO fluctuations. It found that some tend to have a much lower ability to oxidize TMA during menstruation.

Now a group of researchers in Italy have checked out the DNA/RNA capabilities of human FMO3 'in vivo' to see if a few steroid hormones did affect FMO3 levels. It seems they found that the main female sex hormone  17β-Estradiol did inhibit FMO3 production. Other hormones they tested did not seem to affect FMO3 production.

Quote :
Dexamethasone, 5α-dihydrotestosterone, thyroid hormone, and progesterone had no effect on the accumulation of Fmo3 mRNA. The use of increased concentration of theophylline inhibited estrogen receptor α (ERα)-mediated transcription of Fmo3 mRNA. 17β-Estradiol inhibited Fmo3 mRNA accumulation.
So it seems now the menstruation-FMO3 inhibition link has been 'explained'. I am not sure if this explanation will now be accepted by all or if it is just one possible explanation. Possibly since it is DNA research it will likely be accepted by all.

New Paper :
Regulation of flavin-containing mono-oxygenase (Fmo3) gene expression by steroids in mice and humans. : Pubmed Abstract link

2007 paper :
Transient trimethylaminuria related to menstruation : link to Full paper



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3 comments:

Anonymous said...

What a good information!Thank you:)

tom said...

hello I have seen some research what shows, DHT to reduce it by 90 percent . the fm03 enzyme

tom said...

ive read that DHt hormone reduced the fm03 enzyme by 90 percent.

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Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.


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