In 2007 a paper was published where adult females who menstruate who have a TMAU diagnosis were TMAU tested daily over 120 days to check their TMA/TMAO fluctuations. It found that some tend to have a much lower ability to oxidize TMA during menstruation.
Now a group of researchers in Italy have checked out the DNA/RNA capabilities of human FMO3 'in vivo' to see if a few steroid hormones did affect FMO3 levels. It seems they found that the main female sex hormone 17β-Estradiol did inhibit FMO3 production. Other hormones they tested did not seem to affect FMO3 production.
Quote :
Dexamethasone, 5α-dihydrotestosterone, thyroid hormone, and progesterone had no effect on the accumulation of Fmo3 mRNA. The use of increased concentration of theophylline inhibited estrogen receptor α (ERα)-mediated transcription of Fmo3 mRNA. 17β-Estradiol inhibited Fmo3 mRNA accumulation.
So it seems now the menstruation-FMO3 inhibition link has been 'explained'. I am not sure if this explanation will now be accepted by all or if it is just one possible explanation. Possibly since it is DNA research it will likely be accepted by all.
New Paper :
Regulation of flavin-containing mono-oxygenase (Fmo3) gene expression by steroids in mice and humans. : Pubmed Abstract linkTransient trimethylaminuria related to menstruation : link to Full paper
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3 comments:
What a good information!Thank you:)
hello I have seen some research what shows, DHT to reduce it by 90 percent . the fm03 enzyme
ive read that DHt hormone reduced the fm03 enzyme by 90 percent.
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