News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

2 January 2014

New paper on certain bacteria cause colon distenstion

I noticed this new paper which is to do with IBS, but perhaps it may someday also have a connection with what is the main complaint on body odor forums, that is 'fecal body odor' (FBO). Technically I think of FBO as 'sulfide and amine' malodor, as the smell of feces is a mix of chemical compounds. Also I think while fecal is the most embarrassing odor, the smells probably vary right across the sulfide and amine spectrum depending on which sulfides or amines are most abundantly produced by the gut flora at anytime, or even perhaps bbeing smells of other things such as hormones. FMO3 is one of a few enzymes that mainly oxidizes small sulfides and amines, which is where FMO3 would come into the equation.

Anyhow, with IBS there is not usually a complaint of systemic odors, so those with IBS and FBO must make up a small % of the IBS group and there must be some other added factor for 'FBO syndrome' (if it is a syndrome). To me the most likely added factor is under-performance of the FMO3 enzyme, making it a syndrome.

Back to the study, people with IBS often complain of a bloated abdomen. There must be a good chance this is caused by excess gas of some sort. In this research paper they seem to be blaming a sulfate-reducing bacteria and enterobacteriaceae rich gut flora for the distended abdomen, and lack of bifidobacteria..They then put this fecal microbiota into germ-free rats who then got the same distended colon, implying this gut flora conditions could be blame for IBS distended colon. Presumably more research is need.

However, to me it seems of interest to people with FBO, as a bloated abdomen is often somethign people with FBO say they have, and sulfate-reducing bacteria are often mentioned as a possible baddie in the gut flora, along with lack of bifidobacteria ( a gut bacteria 'goodie').

At this point I believe there is no understanding of 'FBO' and we need to wait until it is understood before any therapies are possible. So I don;t think trying anything due to this research will prove to be beneficial yet, as too little is understood. But nevertheless it is an interesting paper. Perhaps sampling done by companies such as Ubiome and AmericanGut will help understand the gut flora composition in those with FBO in the near future.

New medical paper : pubmed
     

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Update Aug 17 :
Genos is back with it's EXOME test
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Note :
Exome/Genome testing may be better option than single gene testing.

See this post : link

Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.


Does Genos fully sequence FMO3 gene ?

At the moment it is not clear, but hoped this will become clear over the next few months

Note : possible 'wild west' way of testing FMO3
Use an ancestry dna site and rummage through the raw data

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