News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

18 November 2012

What therapies/cures could there be for systemic fecal body odor ?

FMO3 malodor sydrome
This is a quick list of my idea of potential therapies/cures for fecal body odor (as they call it on the forums, probably this is the most distressing malodor but it seems to be an even wider spectrum of malodors that that). I am assuming the malodors are due to FMO3 deficiency/overload. I believe that TMAU only has a rotten fish smell, and the other malodors they mention are due to other FMO3 sunstrates (sulfides and amines).

Gene therapy : This would seem a potential 100% cure (?). The Western world has tread lightly with this therapy but now it seems to be speeding up into a reality. The first drug and research studies are being done in the West now.

Oral FMO3 supplementation : This has been suggested but I am not sure of the practicalities. FMO3 is normally present in a cell, unlike other enymes such as digestive enzymes. Whether there is a simple reason it could not be used, I do not know.

FMO3 probiotic : The idea here would be to take a probiotic that has lots of FMO3 which then can oxidize FMO3 substrates it meets in the gut. It wouldn't be a cure as such, but hopefully could reduce the load from the gut.

Block the production of FMO3 substrates : This would work for trimethylamine, but since I think manuy other FMO3 substrates are likely to cause the odors, I am not sure how big a difference it would make to block TMA. Worht a go though.

Probiotic therapy : I feel that often FMO3 malodor is a syndrome and will include gut dysbiosis as part of the syndrome, resulting in overload of the FMO3 enzyme. Whether any old probiotic could help, or whether it has to be taken as a certain probiotic, and perhaps taken as a suppository, I do not know. Fecal transplant therapy seems to be showing good results for C Difficle infection.

These are the main areas I think of when I think of therapies and cures. Hopefully there are many other possibilities. 


Anonymous said...

Why is it that persons experiencing the secretion of these odors can't smell the odors themselves?

Anonymous said...

If you wear the same perfume time and time again,your nose soon becomes accustomed to it that you can't smell the scent like you used to,same with people who have bad armpit odours,usually have to be told they have a problem by someone else

sysbodyodor said...

That's true. The olfactory receptors become saturated or accustomed I guess.

With metabolic malodors, my own opinion is that the brain ignores malodors circulating in the blood. This would be different from the above paragraph.

TMAU Stories

Get New Posts by Email

systemic BO/halitosis important links

MEBO Research malodor study 2016


FMO3 reference

Blog Archive

TMAU/FMO3 research

Systemic Body Odor links

email :

Do you have systemic body odor ?

FMO3 Survey Form

FMO3 DNA test result survey
for those who have FMO3 DNA tested
survey still OPEN

TMA blocker pill (links)

P&G - Cleveland press release aug 2015
1st mention of 'DMB pill' dec 2015
FMO3 DNA testing
Update Aug 17 :
Genos is back with it's EXOME test

Note :
Exome/Genome testing may be better option than single gene testing.

See this post : link

Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.

Does Genos fully sequence FMO3 gene ?

At the moment it is not clear, but hoped this will become clear over the next few months

Note : possible 'wild west' way of testing FMO3
Use an ancestry dna site and rummage through the raw data

TMAU Webinar #5 : Preti et al