News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

26 October 2012

new paper confirms connection with PYROXD2 and trimethylamine metabolism

abstract : PYROXD2 and TMAU ?
Until recently, trimethylamine has generally only been associated with the FMO3 enzyme ; the FMO3 enzyme oxidizing trimethylamine to trimethylamine oxide. However a paper last year suggested that the enzyme PYROXD2 (pyridine nucleotide-disulphide oxidoreductase domain 2) may also be able to metabolize trimethylamine in humans. Presumably this may mean that deficiency of PYROXD2 enzyme may also cause TMAU in humans ?

2011 paper suggesting link between TMAU and PYROXD2 enzyme

Now it seems that more research has been done on this theory, and a new paper by researchers at the Nestle Reseach Center 'confirms' the PYROXD2 and TMAU connection
...Moreover, we report some of our recent GWAS results on a cohort of 265 individuals from an ethnically diverse population that validate and refine previous findings on gene-urine metabolism interactions. Specifically, our results confirm the effect of PYROXD2 polymorphisms on trimethylamine metabolism and suggest that a previously reported association of N-acetylated compounds with the ALMS1/NAT8 locus is driven by SNPs in the ALMS1 gene...
At the moment it cannot be said how this will affect a TMAU diagnosis. It seems that at this point it is not even known what PYROXD2 does.

Abstract for new PYROXD2 paper  


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Update Aug 17 :
Genos is back with it's EXOME test

Note :
Exome/Genome testing may be better option than single gene testing.

See this post : link

Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.

Does Genos fully sequence FMO3 gene ?

At the moment it is not clear, but hoped this will become clear over the next few months

Note : possible 'wild west' way of testing FMO3
Use an ancestry dna site and rummage through the raw data

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