News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

7 May 2012

Fecal Body Odor : Barmaid couldn't smell me

This is an anecdotal story of why I believe some people have a genetic 'anosmia' (or probably more likely a higher sensory threshold) to people with 'fecal body odor' (or call it 'sulfide and amine body odor' or 'FMO3 substrate body odor')

I was in a bar sitting at the bar one time, say quarter full, no noticeable music playing. A guy sitting about 5 feet to my right said to the barmaid 'smell that guy' and the barmaid said 'I can't smell anything'. I believe her.

This has happened to me a few times and it is my belief that a sizeable minority of people cannot smell someone with a FMO3 issue due to genetic reasons probably to do with the same enzyme. This may also be true for other enzyme disorders that cause a smell. I'm guessing many people carry the variants for FMO3. Presumably the number carrying mutants is much lower. But you can end up a 'compound heterozygote' where you are carrying certain variants in an order that can cause FMO3 deficiency at times.

On the good side this means that perhaps 5-20% (my estimate) cannot smell you when you smell, so to them you are not odorous. This may not be true for 'severe' genetic FMO3 cases (I don't know). However I guess 'mild' and 'severe' cases even have a bigger desensitivity to the odors than 'carriers'. Personally I believe about 1% of the population could be 'at risk' of FMO3 substrate overload at times.

Something to think about.

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Update Aug 17 :
Genos is back with it's EXOME test
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Note :
Exome/Genome testing may be better option than single gene testing.

See this post : link

Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.


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