News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

17 November 2011

TMAU1 and TMAU2

People can get confused with primary and secondary TMAU. Basically, TMAU1 is where the FMO3 enzyme is deemed to be subnormal function due to genetics. TMAU2 is all other forms, but mostly seems to be people with normal FMO3 enzyme fuinction (?) and a huge overload of TMA, presumed to be caused by bacteria overgrowth

An analogy would be :

1. Genetic : bucket too small
2 Substrate overload : normal bucket overflowing

Personally I think TMAU is 'fish odor syndrome', and is an ideal marker of FMO3 amine oxidizing capacity, but in my opinion loads of other FMO3 substrates (perhaps 100's) are what cause the smells that people have, with TMA perhaps being a small player in the mix of odors. Not unless fish is a main odor.

What's happening is that people go to a Dr saying they have 'fecal body odor' (a wide mix of odors) and then are being tested for one metabolite (TMA), which being the perfect FMO3 function marker, they fail and are labelled with. Until they start testing for all the other malodorous volatile organic compounds, that is where we are stuck

1 comments:

Anonymous said...

I would like to know about any treatments new or old for this condition. I have beem suffering for years. My doctor thinks its all in my head. I have been taking chlorophyll and activated charcoal it helps some.the smell has dissipated but its still there is there anything else I can try?

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Update Aug 17 :
Genos is back with it's EXOME test
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Note :
Exome/Genome testing may be better option than single gene testing.

See this post : link

Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.


Does Genos fully sequence FMO3 gene ?

At the moment it is not clear, but hoped this will become clear over the next few months

Note : possible 'wild west' way of testing FMO3
Use an ancestry dna site and rummage through the raw data

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