News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

20 October 2017

Could low Choline cause the smells ?

Spec thought :
Could LOW PLASMA CHOLINE cause the smells associated with FMO3 enzyme ?

For now it's a spurious idea, but I wonder if the smells associated with FMO3 enzyme weakness/overload might be caused by a LOW PLASMA CHOLINE level.
Probably not, but something to think about.

How could the person have low plasma choline ?
The gut bacteria break down the choline in the gut before it can be absorbed into the bloodstream.

Some things choline plays a role in :
Seems to play a role in brain function.
Deficiency seems to be associated with Fatty Liver.
It seems it is a main part of the mucus in the colon that protects the gut.   

Is any test lab bothered about Choline ?
It seems not.
So far, no lab testing choline plasma level can be found.
The health-system ignores choline testing.

So for now, this is a very speculative idea.
But a guess would be that even if not connected to smelling, 'TMAU' cases may be naturally prone to a choline plasma deficiency.

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TMA blocker pill (links)

P&G - Cleveland press release aug 2015
1st mention of 'DMB pill' dec 2015
FMO3 DNA testing
Update Aug 17 :
Genos is back with it's EXOME test

Note :
Exome/Genome testing may be better option than single gene testing.

See this post : link

Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.

Does Genos fully sequence FMO3 gene ?

At the moment it is not clear, but hoped this will become clear over the next few months

Note : possible 'wild west' way of testing FMO3
Use an ancestry dna site and rummage through the raw data

TMAU Webinar #5 : Preti et al