News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

10 March 2016

Meldonium, Sharapova, and TMAU

I have mentioned previously that the Latvian makers of the drug Meldonium have marketed it for the CVD market and suggested it may help interfere with TMA production in humans.

Now it seems the tennis player Maria Sharapova and many other athletes have been taking meldonium for years under the premise it helps athletic performance.

My thoughts on the Sharapova/Meldonium news story :
Meldonium is only on sale in Latvia and a few former USSR countries. It's never been available in USA
It's meant as some sort of heart disease drug
The makers say it should only be taken maybe 6 weeks at a time

In relation to reducing TMA for TMAU people (my thoughts)
The only papers on it perhaps reducing TMA formation in humans was by the makers recently
There doesn't look much evidence to me
It's a drug, so I'm very wary
It's not something I have contemplated using
As said above, it's not meant to be taken permenantly

So overall, it's not something I will be following up on. I don't think it's a good lead. I think most people with 'fecal body odor' in fact have problems with all FMO3 sulfides and amine substrates (and maybe phosphates), and not just TMA, so I'm not a big believer in reducing TMA alone anyway.

I'm hoping the publicity on meldonium may indirectly raise public awareness of TMAU, though it does not look like it. I'm assuming Sharapova does not have a smell problem :)  

Daily Mail : meldonium for 6 week use only (mar 16)
Daily Mail : many athletes use meldoium (mar 16)
Daily Mail : meldonium inventor opinion (mar 16)
Daily Mail : meldonium 'not doping' (mar 16)
Daily Mail : experts question meldonium use (mar 16)

pubmed paper : meldonium and trimethylamine
wikipedia : meldonium
Acronyms :
TMA : trimethylamine
TMAU : trimethylaminuria

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TMA blocker pill (links)

P&G - Cleveland press release aug 2015
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FMO3 DNA testing
Update Aug 17 :
Genos is back with it's EXOME test

Note :
Exome/Genome testing may be better option than single gene testing.

See this post : link

Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.

Does Genos fully sequence FMO3 gene ?

At the moment it is not clear, but hoped this will become clear over the next few months

Note : possible 'wild west' way of testing FMO3
Use an ancestry dna site and rummage through the raw data

TMAU Webinar #5 : Preti et al