News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

14 August 2015

TMA-O paper : Mice and liver damage

The 2011 paper suggesting that TMA-oxide may be a key cause of CVD has meant there has since been much interest in trimethylamine metabolism in humans whereas before there was almost none. There are now maybe 1 or 2 papers a week published about TMAO/TMA etc. Usually to see if it may be associated with a serious disorder or to do with CVD

In this new Chinese paper I don't see anything remarkable. It is posted more to demonstrate the constant stream of papers.

They seem to have fed mice high TMA-Oxide diets and conclude TMAO may be associated with liver damage in them.

Protective effects of tartary buckwheat flavonoids on high TMAO diet-induced vascular dysfunction and liver injury in mice : Link

What has this to do with Systemic Body Odor ?
It is my current belief that most cases of systemic body odor are to do with FMO3 enzyme, which oxidizes many sulfides and amines. So any research to do with TMA metabolism  or FMO3 in humans may in my opinion be of interest to those with systemic body odor too.  


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FMO3 DNA testing
Update Aug 17 :
Genos is back with it's EXOME test
link

Note :
Exome/Genome testing may be better option than single gene testing.

See this post : link

Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.


Does Genos fully sequence FMO3 gene ?

At the moment it is not clear, but hoped this will become clear over the next few months

Note : possible 'wild west' way of testing FMO3
Use an ancestry dna site and rummage through the raw data

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