The study was carried out by a hospital in London Ontario. They measured the TMAO plasma levels in 479 subjects, 106 of who had IBD.
Link to abstract : Trimethylamine-N -oxide: A Novel Biomarker for the Identification of Inflammatory Bowel Disease
Why the interest in TMAO ?
Probably the research interest in what TMAO has to do with health is because of the Hazen et al paper about 4 years ago that suggested a link with high TMAO levels and atherosclerosis, perhaps suggesting a link between the 2, or TMAO being a biomarker at least. Since then there have been various papers testing TMAO with health conditions. I believe there was a paper suggesting a link with diabetes.
Study in context :
It should be said that these type of studies are floated initially, and then over time they are either accepted as the consensus or not. A bit like climate change can still be argued against. So one study is unlikely to make the whole health community accept it as fact.
What's this to do with systemic/metabolic malodors ?
It is my own current belief that FMO3 enzyme is repsonsible for most cases of 'metabolic/systemic malodor', as it oxidizes many sulfides and amines. Currently only trimethylamine is the only volatile documented as causing metabolic malodor, and TMA should be oxidized to TMAO by FMO3. So anything to do with TMA/TMAO/FMO3 is of interest to me. If the health system is interested in TMAO then it will hopefully lead to further research into TMA/TMAO/FMO3, which have all been largely ignored.
Also many in the metabolic/systemic malodor community report of having vague/acute 'gut dysbiosis' type problems such as 'irritable bowel syndrome'. I believe there is a connection with FMO3 and it may be part of a metabolic maldor 'syndrome'.
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