Research inspired by Dr Hazen's theory that TMAO may be a risk factor in cardiovascular disease.
Research paper abstract :
Intestinal microbiota composition modulates choline bioavailability from diet and accumulation of the proatherogenic metabolite trimethylamine-N-oxide : link
Romano KA, Vivas EI, Amador-Noguez D, Rey FE
University of Wisconsin-Madison, Madison, Wisconsin, USA
I have mentioned before that the hypothesis by Dr Hazen et al at the Cleveland Clinic first proposed in 2011 would lead to a lot of research into trimethylamine metabolism, which in turn would be beneficial research for people with trimethylaminuria (TMAU). Up until the CVD hypothesis (still being debated), there was little to no interest in TMA metabolism or FMO3 enzyme.
I have read only the abstract of the paper. It seems they are microbiologists who are aware of the TMAO-CVD hypothesis and aware that almost nothing (perhaps nothing at all) is known as to which bacteria in the gut break down choline to trimethylamine.
The abstract does not say which bacteria break down choline to trimethylamine in the gut. It seems they tested 79 common gut types in a mouse.
Interesting observation about choline in the paper :
The paper says " Remarkably, low levels of colonization by TMA-producing bacteria significantly reduced choline levels available to the host.". This is a surprising observation. I would have thought the less tma-producing bacteria in the gut you have, the less choline that is available to the host. I guess we will need to wait for more evidence on this observation
My final comment :
It's great that the CVD-TMAO hypothesis of 2011 is leading to interest in TMA metabolism in humans. It's a coincidental bit of good fortune for people who feel they have TMAU only as it has lead to more research around the world into TMA metabolism and FMO3 enzyme (or even for those who feel FMO3 may be more to blame for their range of malodors, as I suspect). Really no research was ongoing into TMA metabolism or FMO3 before this hypothesis.
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