In January 2015 it was suggested by Hazen et al (in research paper) that TMAO may be associated with chronic kidney disease
This new paper commissioned by the National Kidney Association seem to suggest they found no connection with TMAO and kidney disease in the 235 chronic kidney disease patients they tested.
March 2015 : Associations of Trimethylamine N-Oxide With Nutritional and Inflammatory Biomarkers and Cardiovascular Outcomes in Patients New to Dialysis : link to abstract
My uneducated interpration of the paper :
It seems they tested the serum TMAO (trimethylamine-n-oxide) levels of 235 patients undergoing hemodialysis due to chronic kidney disease. Thier conlcusoion seems to be that there was no connection with TMAO levels and cardiovascular health.
My comment on the paper :
This is a common development in the research community when a new theory is put forward. Once the theory is made public, then other labs will test the theory and then a consensus will happen. Same as climate change arguments, I guess. My own feeling is that the TMAO-CVD connection has yet to be conclusively proven but the lab that suggested the theory is world-wide respected. So, to me the jury is still out. In this case the connection was with chronic kidney disease, which was a new angle for the TMAO theory put forward in January this year.
Whatever the outcome, I think there will be worldwide interest in trimethylamine metabolism in humans for a few years yet, and that is good news for people with TMAU and possibly for those with FMO3 enzyme deficiency too.
Other links
Hazen et al paper Jan2015 :
Gut Microbiota-Dependent Trimethylamine N-Oxide (TMAO) Pathway Contributes to Both Development of Renal Insufficiency and Mortality Risk in Chronic Kidney Disease
Cleveland Clinic article on the 'TMAO-Chronic kidney disease' paper
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