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| TMAO and CRC connection ? |
Plasma choline metabolites and colorectal cancer risk in the Women's Health Initiative Observational Study
Bae S et al, Cornell University NY
TMAU connection :
The main connection is that TMAO has now been hypothesized as being connected with Coronary Vascular Disease (CVD) and now for the first time also colorectal cancer (CRC). These being two major diseases, it is likely there will now be much research about trimethylamine production in humans and how to stop/negate it. Obviously this would also benefit those with trimethylaminuria.
Main benefit :
It means now there will likely be much more research into TMA production in humans and a lot of money put into the research. So rather than TMAU/FMO3 research now being only associated with a 'rare'(?) disorder and little interest in research, now it is likely to get a lot of attention and TMAU will likely benefit from this research
My own opinion :
I think this is great news. However since most of us tend to smell of bowel smells (and other malodors), I personally suspect that someone with 'TMAU' actually has 'FMO3 substrate malodor' (FMO3 oxidizes 1,000s of sulfides and amnines of a particular structure) where any FMO3 substrate in large doses can make the person smell. So I am a bit pessimistic that something that stops TMA production will totally stop the malodors in someone with an FMO3 issue, HOWEVER I MAY BE WRONG.
Overall though, the fact the 2 major diseases are being hypothesized as being associated with TMAO (hopefully they aren't) means that a lot of money will now be put into research into TMA and how to stop/negate it etc.
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