What therapies/cures could there be for systemic fecal body odor ?

FMO3 malodor sydrome

This is a quick list of my idea of potential therapies/cures for fecal body odor (as they call it on the forums, probably this is the most distressing malodor but it seems to be an even wider spectrum of malodors that that). I am assuming the malodors are due to FMO3 deficiency/overload. I believe that TMAU only has a rotten fish smell, and the other malodors they mention are due to other FMO3 sunstrates (sulfides and amines).

Gene therapy : This would seem a potential 100% cure (?). The Western world has tread lightly with this therapy but now it seems to be speeding up into a reality. The first drug and research studies are being done in the West now.

Oral FMO3 supplementation : This has been suggested but I am not sure of the practicalities. FMO3 is normally present in a cell, unlike other enymes such as digestive enzymes. Whether there is a simple reason it could not be used, I do not know.

FMO3 probiotic : The idea here would be to take a probiotic that has lots of FMO3 which then can oxidize FMO3 substrates it meets in the gut. It wouldn't be a cure as such, but hopefully could reduce the load from the gut.

Block the production of FMO3 substrates : This would work for trimethylamine, but since I think manuy other FMO3 substrates are likely to cause the odors, I am not sure how big a difference it would make to block TMA. Worht a go though.

Probiotic therapy : I feel that often FMO3 malodor is a syndrome and will include gut dysbiosis as part of the syndrome, resulting in overload of the FMO3 enzyme. Whether any old probiotic could help, or whether it has to be taken as a certain probiotic, and perhaps taken as a suppository, I do not know. Fecal transplant therapy seems to be showing good results for C Difficle infection.

These are the main areas I think of when I think of therapies and cures. Hopefully there are many other possibilities. 

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By sysbodyodor

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Probiotic retained enema for Fecal Body Odor ?

probiotic infusion ?

I suspect metabolic 'Fecal Body Odor' is often a syndrome, based upon a genetic issue (in my opinion to do with FMO3 enzyme), but also has other factors that make up the syndrome. One of these factors might often be a certain type of 'gut dysbiosis'. Over the last 10 years or so the idea of 'fecal transplantation' has become 'discussed' among the communities with disorders such as Ulcerative Colitis and other bowel disorders. I think it may have a role in 'fecal body odor syndrome' but prefer the idea of a 'probiotic enema' rather than a fecal transplant. My wariness is because with a fecal transplant I don't know what you are getting (good, bad and ugly ?) So in the future I think there may be a role for probiotic infusions in disorders related to gut dysbiosis.

This paper seems to be looking for the right 'probiotic cocktail' mix for probiotic infusions, doing away with the need of a fecal donor.
Restoration of gut flora in mice using probiotic mix
Article in Science Daily news

So I will follow research into this with interest, though I do not know what to think of it currently.

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By sysbodyodor

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