News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

21 September 2012

Could TMA producing bacteria cause a blood choline deficiency ?

This is a question I have thought of for a while. Choline is reasonably important in proper human function, especially in helping with liver function ? It was not until 1998 it was officially classified as an essential nutrient in the USA.

My theory was that there is a possibility of a lose-lose situation for people who tend to produce trimethylamine in their gut. A lot of the trimethylamine seems to be from gut 'feeding' on choline, with one of the bi-products being trimethylamine. But presumably that then uses up choline from the diet meaning less available for absorption into the bloodstream.  

The only way we would find out if this was an issue in those with a FMO3 overload or deficiency issue is for them to have a choline blood test. I am not sure how easy it is to access a choline blood test. I saw on the Biolab UK site they mention they test for free and total choline. It would be interesting to see how the FMO3 overload or deficiency community do with this test. If you test let us know your result and anything else you think would help.

Links :
Choline entry in wikipedia


karysmar said...

Thank you for this post. it is very helpful

TMAU Stories

Get New Posts by Email

systemic BO/halitosis important links

MEBO Research malodor study 2016


FMO3 reference

Blog Archive

TMAU/FMO3 research

Systemic Body Odor links

email :

Do you have systemic body odor ?

FMO3 Survey Form

FMO3 DNA test result survey
for those who have FMO3 DNA tested
survey still OPEN

TMA blocker pill (links)

P&G - Cleveland press release aug 2015
1st mention of 'DMB pill' dec 2015
FMO3 DNA testing
Update Aug 17 :
Genos is back with it's EXOME test

Note :
Exome/Genome testing may be better option than single gene testing.

See this post : link

Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.

Does Genos fully sequence FMO3 gene ?

At the moment it is not clear, but hoped this will become clear over the next few months

Note : possible 'wild west' way of testing FMO3
Use an ancestry dna site and rummage through the raw data

TMAU Webinar #5 : Preti et al