News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

16 November 2011

Interpreting your TMAU phenotype (urine) test result

At first, interpreting a TMAU urine test result may seem daunting, but it is really very simple.It's like e=mc2 sounds daunting but is really easy when you understand.

For the TMAU urine test, there are 2 main metabolites tested
trimethylamine (TMA)
and trimethylamine-n-oxide (TMAO)

Basically, if the TMA is over a set limit, you are deemed to have TMAU

If the TMA/TMAO ratio is over a set limit, you are deemed to have primary TMAU1
This is often expressed as the TMAO % (equation TMA + TMAO/TMAO)

That's it. Unfortunately, there is no agreement between the labs that test to the set limits (each have their own reference range). To make it more confusing, it seems many of the labs have not set a limit for TMA, and only go by the ratio (therefore, refuse to label anyone as secondary TMAU). If you have the figures you can work out yourself roughly if you would be TMAU2. If you only have the ratio or %, you cannot.

Conversely, some labs only give the TMA level as a result, and do not measure TMAO. This means you do not know how much of the TMA you oxidized, and you do not know if you are TMAU1 or TMAU2

There are other problems with the testing procedures, such as some saying no load is needed, and others saying choline, while others say fish. It is a bit of a minefield.

My own personal preferred option would be to take a load of TMA (probably around 600mg) and see what the TMA and TMAO levels are. This is a straight test of how well your FMO3 enzyme copes with a fixed load of TMA. From there I would then maybe want to find out if bacterial growth is a big factor, by taking a choline load. Overall though, I am not majorly concerned at the moment about bacterial overgrowth, but rather how well the enzyme functions.

Creatinine is also measured in TMAU urine test. This is basically merely as something to reference the TMA and TMAO levels against.

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Update Aug 17 :
Genos is back with it's EXOME test
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Note :
Exome/Genome testing may be better option than single gene testing.

See this post : link

Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.


Does Genos fully sequence FMO3 gene ?

At the moment it is not clear, but hoped this will become clear over the next few months

Note : possible 'wild west' way of testing FMO3
Use an ancestry dna site and rummage through the raw data

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