Trying antibiotics for fecal body odor

I have had 'intermittent fecal body door' for a number of years. Recently I have decided to try the 'antibiotic route' to see how it goes. So far, having tried 3 antibiotics, I do not seem to be any further along. A main concern is that candida may be a (main) factor. As a reminder though, I must point out that I think it is a FMO3 genetic enzyme deficiency at the root of the problem, but I do think gut dysbiosis is also a factor.

For the record, here is what I have tried and my impression of the result

Antibiotic	Dosage	Comment
Flagyl	400mg twice daily for 2 weeks	Difficult to take. Metallic taste, nightmares etc.. No obvious improvement. Conclude it is too harsh
Amoxycillin	500mg	Not as bad reaction as flagyl but still quite difficult, and no obvious improvement
Doxycycline	100mg 1 a day for 14 days	Easiest to tolerate but still quite difficult. Did not feel any improvement

Summary : The above antibiotics did not seem to improve my odor or gut dysbiosis and were quite difficult to tolerate, which I suspect is due to being unable to metabolize the drugs efficiently.

I am going to try a few more. Like rifaximin and neomycin

Gut dysbiosis :
This is due to microbes causing a pathogenic environment in the gut. It could be bacteria, fungus, or parasites. It can be in the stomach, small intestine, or colon. Currently orthodox medicine would only think bacteria is the problem, but I don't agree.

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By sysbodyodor

experiment, personal treatment

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Why fecal body odor and gas body odor ?

Image For visual purpose only 

This is a post about 'fecal body odor' coming through the skin

Gas body odor will be when the mcirobes are 'partying'
Fecal body odor will be when the microbes have died

That seems to be the rule for gas and fecal smells. Gas, or 'fart', is when the microbes are 'feasting' (the odor being the bi-products of their 'feast'.  Fecal odor is when the microbes have died (so it's the smell of gut microbe death, in a sense)

Usually these compounds are probably sulfides or amines mostly, possibly to be detoxified by the FMO3 enzyme

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By sysbodyodor

fecal body odor, fmo3, systemic body odor

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Why is FMO3 such a suspect for fecal body odor ?

My own suspicion is that enzyme FMO3 is most likely to blame for 'fecal body odor' (although recently I have started more considering hypermethionemia as a potential suspect enzyme too). Still, at the moment I suspect 'fecal body odor' may be 'FMO3 body odor'.

Here's why :

Many enzymes deal with 1 or only a few 'substrates' (i.e. metabolites), that tend to have the same construction and if they have an odor it is likelty to be a particular odor (such as sweaty feet odor in isovaleric acidemia). FMO3 deals with 1,000s of various substrates that have a sulfur, nitrogen, or phosphorous molecule (in particular, sulfides and amines are known to be smelly)

FMO3 is a drug metabolizing enzyme, a xenobiotic metabolizing enzyme, a endogenous metabolizing enzyme,  which deals with 1,000's of substrates

Most other enzymes seem to be mostly endogenous metabolizing enzymes that have very few substrates

At the moment it is known that trimethylamine is a FMO3 substrate and the only one known to have no alternative route for oxidation. Although there are 1,000s of other FMO3 substrates, currently experts believe only TMA will cause a smell. They must think that either the other substrates with no alternative pathway are unknown, or that they can go alternative pathways for oxidizing. My opinion is that it is very possible the other pathways become 'backed up' with these constant load of FMO3 substrates, most coming from the gut.

So, for now, I still think 'fecal body odor' is 'FMO3 body odor', but this is before any proof one way or the other is demonstrated. I am open-minded for it being another enzyme (or even a few enzymes)

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By sysbodyodor

fecal body odor, fmo3

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