News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

Possible/Potential Therapies/Cures for Systemic Body Odor


Potential Therapies  
Quick ref (for FMO3/TMAU).
titles :
Drug Repurposing.
TMA blocker.
Methane Pathway (TMA to methane ... using cloned enzyme from microbe ... 'probiotic').
Gene Therapy.
FMO3 oral pill (to act in gut).
Ataluren (for NONSENSE mutations only).

Systemic Body Odor will likely be due to mainly 2 factors :
1. weakness in a metabolic enzyme.
2. substrate overload (of an enzyme).

My long-time suspicion is the enzyme to blame is ... FMO3.
Until persuaded differently.

Other potential suspect enzymes :
Oxidizing enzymes (e.g. CYP450 enzymes).
Conjugation enzymes (unlikely imho. They would smell of certain smells imho.)

FMO3/TMAU therapies

DRUG REPURPOSING  to improve FMO3 function
chances of success (imho) : 9/10
benefit : 10/10

Repurposing is where old drugs are tried on FMO3 cells to see if any improve function without side effects.
This is a well-used format in pharma research.
A Metabolic Consultant is willing to put FMO3 'through the ringer' but they need around $80 USD to employ someone fulltime for the 2 year study.
This has a very good chance of success. 

What's needed :
A trusted party (person or group) to raise the funds.
Current outlook : not good.
blog post on this

'Drug the TMA causing bacteria'.
Cleveleand Clinic 'DMB' work :
Aim is to create a choline mimic that confuses the bacteria to sluggishly produce TMA.
P&G agreement Aug 2015.
When to market ? Unknown. Could be 1-5 years. So far has only done mice-work.

'TMA to Methane bacteria' (trimethylamine-dehydrogenase enzyme)
Methane producing bacteria break down TMA to methane.
Previously would have needed to take microbe with the enzyme.
Now would clone the enzyme to known harmless gut microbe.
Probably take enzyme from Archaea.
Optimism score : 80% ?
Could be done now ? probably.
Chances of happening : currently 10% ?

This post is a work in progress




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for those who have FMO3 DNA tested
survey still OPEN

TMA blocker pill (links)

P&G - Cleveland press release aug 2015
1st mention of 'DMB pill' dec 2015
FMO3 DNA testing
Update Aug 17 :
Genos is back with it's EXOME test
link

Note :
Exome/Genome testing may be better option than single gene testing.

See this post : link

Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.


Does Genos fully sequence FMO3 gene ?

At the moment it is not clear, but hoped this will become clear over the next few months

Note : possible 'wild west' way of testing FMO3
Use an ancestry dna site and rummage through the raw data

TMAU Webinar #5 : Preti et al