In this they check the TMAO plasma levels of 27 people over a year giving Vit D to 1 group, and vit D + some B vits to another (?).
The conclusion seems to be that Vit D + B vits lowered plasma.
Personally I don't take much from the study.
Paper : Plasma TMAO and B vits + Vit D
research by German and Danish group
Why was this paper done :
Because of the Cleveland Clinic 2011 theory that TMAO may be a big causal factor in CVD. Since then, I guess atherosclerosis researchers worldwide have been testing if there's any connection between known proposed 'help' to avoid heart disease and TMAO levels. In this case they checked Vit D and some B vits. I have not heard of the labs before. It seems pretty random to me (small group etc) though they did test them for a year it seems.
Quote from paper :
"CONCLUSION:
B-vitamins plus vitamin D lowered plasma fasting TMAO compared with vitamin D. Vitamin D caused alterations in choline metabolism which may reflect the metabolic flexibility of C1-metabolism. The molecular mechanisms and health implications of these changes are currently unknown."
"CONCLUSION:
B-vitamins plus vitamin D lowered plasma fasting TMAO compared with vitamin D. Vitamin D caused alterations in choline metabolism which may reflect the metabolic flexibility of C1-metabolism. The molecular mechanisms and health implications of these changes are currently unknown."
What's this to do with systemic body odor ?
TMAU is the only fairly well documented 'systemic body odor' disorder. So any research to do with TMA metabolism will be of interest.
My own view :
This won't change anything for me. I tend to find B vits a struggle. Don't know why. I think they are often methyls. Personally I think we need to look at testing rather than guessing with supplements. I will be taking the P&G TMA-blocker pill when it comes out. So I won't be taking vit B, D for 'TMAO plasma levels'.
My view on systemic body odor :
My own view is that perhaps most have an issue with FMO3 enzyme function, rather than just the volatile TMA alone. FMO3 enzyme alters many sulfide,amine and phospine containing volatiles. I think FMO's were intended to deal with poisons in plants.
So I am not much excited about 'TMA therapies' alone, but will still be trying them when they are avialable.
Acronyms :
CVD : cardiovascular disease
TMA : trimethylamine
TMAO : trimethylamine oxide
TMAU : trimethylaminuria
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