News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

5 September 2016

TMAO reduced by vit D + B vits

New TMAO paper.
In this they check the TMAO plasma levels of 27 people over a year giving Vit D to 1 group, and vit D + some B vits to another (?).
The conclusion seems to be that Vit D + B vits lowered plasma.
Personally I don't take much from the study.

Paper :  Plasma TMAO and B vits + Vit D 
research by German and Danish group

Why was this paper done :
Because of the Cleveland Clinic 2011 theory that TMAO may be a big causal factor in CVD. Since then, I guess atherosclerosis researchers worldwide have been testing if there's any connection between known proposed 'help' to avoid heart disease and TMAO levels. In this case they checked Vit D and some B vits. I have not heard of the labs before. It seems pretty random to me (small group etc) though they did test them for a year it seems.

Quote from paper :

"CONCLUSION:
B-vitamins plus vitamin D lowered plasma fasting TMAO compared with vitamin D. Vitamin D caused alterations in choline metabolism which may reflect the metabolic flexibility of C1-metabolism. The molecular mechanisms and health implications of these changes are currently unknown."

What's this to do with systemic body odor ? 
TMAU is the only fairly well documented 'systemic body odor' disorder. So any research to do with TMA metabolism will be of interest.

My own view :
This won't change anything for me. I tend to find B vits a struggle. Don't know why. I think they are often methyls. Personally I think we need to look at testing rather than guessing with supplements. I will be taking the P&G TMA-blocker pill when it comes out. So I won't be taking vit B, D for 'TMAO plasma levels'.

My view on systemic body odor :
My own view is that perhaps most have an issue with FMO3 enzyme function, rather than just the volatile TMA alone. FMO3 enzyme alters many sulfide,amine and phospine containing volatiles. I think FMO's were intended to deal with poisons in plants.
So I am not much excited about 'TMA therapies' alone, but will still be trying them when they are avialable.

Acronyms :
CVD : cardiovascular disease
TMA : trimethylamine
TMAO : trimethylamine oxide
TMAU : trimethylaminuria


Get new posts by email


0 comments:

re Email sub service : Google is stopping this service JULY 21 new post emails will no longer happen

TMAU Stories

systemic BO/halitosis important links

MEBO Research malodor study 2016

Youtube

FMO3 reference

Blog Archive

TMAU/FMO3 research

Systemic Body Odor links

email :
sysbodyodor@gmail.com

Do you have systemic body odor ?

FMO3 Survey Form

FMO3 DNA test result survey
for those who have FMO3 DNA tested
survey still OPEN

TMA blocker pill (links)

P&G - Cleveland press release aug 2015
1st mention of 'DMB pill' dec 2015
FMO3 DNA testing
Update Aug 17 :
Genos is back with it's EXOME test
link

Note :
Exome/Genome testing may be better option than single gene testing.

See this post : link

Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.


Does Genos fully sequence FMO3 gene ?

At the moment it is not clear, but hoped this will become clear over the next few months

Note : possible 'wild west' way of testing FMO3
Use an ancestry dna site and rummage through the raw data

TMAU Webinar #5 : Preti et al