Another paper by Hazen et al re TMAO.
Seems to suggest TMAO shown to cause vascular inflammation.
All this CVD - TMAO research will likely help with therapies for TMAU
Yet another paper from the Hazen lab at Cleveland Heartlab re the proposed TMAO - CVD theory. This one was a joint paper with a LA Uni lab. They seem to suggest TMAO plays in role in inflammation of the vascular tissue. I think inflammation damage here is thought to be the main cause for CVD problems. Maybe this is the 1st paper to show the exact role TMAO plays in CVD, though I haven't been paying close attention to the CVD role.
Relevance to TMAU :
If someone thinks their sole source of malodor is TMA, then this research will be of great interest, because they will likely look for ways to stop TMA formation in the gut. Already there is talk of a DMB pill which interferes with TMA formation, but this could take months/years to come to the market.
Link
Hazen et al Cleveland-LA TMAO paper Feb 2016
My opinion :
It's a lucky break for systemic malodor people that this CVD-TMAO theory was proposed in 2011. Up until then no-one had interest in TMA metabolism in humans. My own view is that most cases of 'fecal body odor' are in fact caused by all FMO3 substrates and not just TMA, but
1: I might be wrong
2 : It will likely lead to more research into FMO3 anyway
3 : TMA reduction will reduce the FMO3 load
My current excitement at this research : maybe 4/10
But I will be stocking up on DMB when it is on sale.
Hazen lab seems to publish TMAO papers at a rate of maybe 10 a year now, so I expect more papers from them this year. Also other labs will likely start to increase papers too.
TMAO : Trimethylamine-n-oxide
TMA : Trimethylamine
DMB : 3,3-Dimethyl-1-butanol (wikipedia)
CVD : Cardiovascular Disease
Look out for :
Heart Disease stories in the news to do with Hazen, Cleveland, TMAO
DMB pill stories (none likely yet)
Procter & Gamble announcement about 'TMAO management' supplement (no sign yet. Could be months-years)
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