News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

9 November 2014

FMO research : Do FMO's affect Vit D or cholesterol metabolism ?

From cholesterogenesis to steroidogenesis: role of riboflavin and flavoenzymes in the biosynthesis of vitamin D
Pinto, Cooper
Department of Biochemistry and Molecular Biology, New York Medical College, Valhalla, NY

Flavin mono-oxygenase research paper
This is a paper researching whether Vitamin D and cholesterol metabolism is affected by FMO enzymes.

Note : I was informed FMO3 will not affect the metabolism of Vitamin D or cholesterol. My understanding about the FMO enzyme family in humans is that currently there are about 5 known FMOs in humans, and FMO3 is currently regarded as the most used and abundant, but that much more may remain to be known about the FMO enzymes.

Importance to those with FMO3 malodor syndrome (if my suspicion that FMO3 is to blame for most people's metabolic malodor) :
There doesn't seem to be a direct connection to malodor. Indirectly it may be important in that it may lead to more interest in researching FMO's in humans.


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TMA blocker pill (links)

P&G - Cleveland press release aug 2015
1st mention of 'DMB pill' dec 2015
FMO3 DNA testing
Update Aug 17 :
Genos is back with it's EXOME test

Note :
Exome/Genome testing may be better option than single gene testing.

See this post : link

Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.

Does Genos fully sequence FMO3 gene ?

At the moment it is not clear, but hoped this will become clear over the next few months

Note : possible 'wild west' way of testing FMO3
Use an ancestry dna site and rummage through the raw data

TMAU Webinar #5 : Preti et al