News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

30 November 2013

research : Archaebiotics: Proposed therapy to prevent trimethylaminuria

What is this ? : new research paper by a group of microbiologists based in France/Ireland (main base is France) 
Who would it potentially help ? : mainly those with trimethylaminuria, but possibly it will help reduce other FMO3 substrates too.
What is the concept  ? : using a microbe that is known to be present in many human colons, that naturally alters trimethylamine in the gut to a methane compound that is inert and odorless, so reducing the absorption of trimethylamine into the bloodstream
What stage are they at ? : At the moment they have just proved the concept, and it is at it's very earliest stages

Full free paper : Archaebiotics: Proposed therapeutic use of archaea to prevent trimethylaminuria and cardiovascular disease

This is research that aims to alter the gut flora to a more friendly type for people with TMAU. It aims to 'negate' the trimethylamine formation in the gut, and so reduce the amount absorbed into to the bloodstream. They term it 'Archaebiotics' since archae is not part of the bacteria family, but it is the same concept as 'probiotics' and 'probtiotic therapy'.

I am not a great believer that 'trimethylamine' alone is the only compound to make people with a FMO3 susceptibility smell (FMO3 oxidizes 1,000s of sulfides and amines), but it may be a major factor and so reducing the TMA load is something to be welcomed. Also it may 'inactivate' other FMO3 substrates, so it may be more helpful than I expect.

I have thought of this type of therapy before and it has been previously speculated a long while ago (my own hope was FMO3 enriched probiotics) but now that a paper has been published showing a connection between trimethylamine-oxide levels and cardiovascular disease, there should hopefully be a lot of research going on worldwide now where they are trying to reduce or block trimethylamine formation in the gut.   


Unknown said...

Any updates on this?

sysbodyodor said...

Last I heard they had got a funding for a small research project. I wouldn't think of it as a major hope for us though. I think they are trying to see if archeabiotics can neutralize trimathylamine or something

TMAU Stories

Get New Posts by Email

systemic BO/halitosis important links

MEBO Research malodor study 2016


FMO3 reference

Blog Archive

TMAU/FMO3 research

Systemic Body Odor links

email :

Do you have systemic body odor ?

FMO3 Survey Form

FMO3 DNA test result survey
for those who have FMO3 DNA tested
survey still OPEN

TMA blocker pill (links)

P&G - Cleveland press release aug 2015
1st mention of 'DMB pill' dec 2015
FMO3 DNA testing
Update Aug 17 :
Genos is back with it's EXOME test

Note :
Exome/Genome testing may be better option than single gene testing.

See this post : link

Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.

Does Genos fully sequence FMO3 gene ?

At the moment it is not clear, but hoped this will become clear over the next few months

Note : possible 'wild west' way of testing FMO3
Use an ancestry dna site and rummage through the raw data

TMAU Webinar #5 : Preti et al