News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

26 August 2012

Osmotic laxative : Laxido was good ; Dulcobalance was bad

I was experimenting with osmotic laxatives recently. Laxido seemed to work 'perfectly', but Dulcobalance made me even more ADHD, agitated, and even constipated (with any stools being of a small amount and messy).

Here are the listed ingredients for both products :
laxido ingredients : 13.125g Macrogol 3350 ... and 350.7mg Sodium chloride, 178.5mg Sodium
hydrogen carbonate and 46.6mg Potassium chloride

dulcobalance ingredients : 10g of macrogol 4000 ... and saccharin sodium, and the orange-grapefruit flavour which contains orange and grapefruit oils, concentrated orange juice, citral, acetaldehyde, linalol, ethyl butyrate, alpha terpineol, octanal, beta and gamma hexenol, maltodextrin, gum arabic, sorbitol (E420)

I have 3 possible theories why dulobalance may have been problematic :
1. Sulfur dioxide included : This may have been the issue. Perhaps the sulfur was feeding sulfur producing bacteria or some other microbe. It says in the leaflet that some are allergic to sulfur though I do not think I am.

2. Grapefruit oils included : compounds in grapefruit are known to inhibit the CYP3A4 enzyme present in the gut of humans. This has a similar function to the FMO3 enzyme (but much more relatively 'important'). Perhaps if my gut CYP3A4 was inhibited it caused a toxic buildup. I suspect this may have been the most likely cause.

3. The size of the macrogol : The macrogol is the basic ingredient that causes osmotic laxatives to induce water into the bowel. I don't know enough to know if the different size could be an issue.

4. Lack of electrolytes : Laxido seems to add balanced electrolytes to the sachet whereas Dulcobalance doesn't add the same mix.

5. Sorbitol : Dulcobalance adds sorbitol which may have fed bacteria in the gut in a certain way when mixed with macrogol.

So in hindsight, I would say Laxido worked the way I expected and Dulcobalance was a disaster. Osmotic laxatives are only meant as a short-term answer to constipation and may cause serious problems if taken long-term (e.g. severe reaction to electrolyte imbalance such as seizure). That said, I wouldn't mind taken much smaller doses of Laxido to make my stool always soft. It was so easy with Laxido.

Bad reaction I had to Dulcobalance : watery itchy eyes, agitated, poor sleep, constipation, infrequent small messy stools, some flatulence, increased tenseness.


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Update Aug 17 :
Genos is back with it's EXOME test

Note :
Exome/Genome testing may be better option than single gene testing.

See this post : link

Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.

Does Genos fully sequence FMO3 gene ?

At the moment it is not clear, but hoped this will become clear over the next few months

Note : possible 'wild west' way of testing FMO3
Use an ancestry dna site and rummage through the raw data

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