News & Views on Systemic Body Odor and Halitosis such as trimethylaminuria TMAU. If you have fecal odors or bowel odors it may be metabolic/systemic

14 November 2011

Systemic Body Odor

There could be a few names for the 'concept' of systemic body odor, where the odors are coming through the pores from the circulation. They all basically mean the same thing :

Metabolic body odor
Systemic body odor
Bloodborne body odor

The main point is that it is not like the type of body odor that people think of as 'body odor', where the odorous compounds are generated on the surface of the skin and can be washed off. With systemic body odor, the compounds are circulating in the person's system for some metabolic reason, and eventually exiting through the pores. They can be circulating due to excessive 'substrate' (chemical) flowing through the body that even someone with normal enzyme function cannot cope with (overload), or it can be that the person has subnormal enzyme function and so even normal amounts of substrate can overload the enzyme. Personally I think in most cases it is probably a bit of both, including in secondary TMAU cases, where people are discouraged from doing the DNA test.

I would also think most cases are a 'syndrome', where they need at least a couple of factors for the overload to happen. One part is 'gut dysbiosis', and the other is slightly subnormal enzyme function. Probably the 2 things go naturally together. Personally I reckon FMO3 probably plays a role in the colon in detoxing sulfides and amines before they are absorbed, but if you are subnormal for FMO3 then the sulfide and amine producing microbes get out of hand and you end up with a bigger load being absorbed than a normal person. Then your liver being deficient in FMO3, it cannot be processed there efficiently either.

Systemic body odor could also be caused by other subnormal enzymes, such as Methionine adenysol transferase. The concept means that abnormal compound(s) is circulating in the blood or lymph, causing an odor.

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Update Aug 17 :
Genos is back with it's EXOME test
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Note :
Exome/Genome testing may be better option than single gene testing.

See this post : link

Note : Genos Exome Testing.

Exome testing is almost the same price now as single gene testing. Also Genos is consumer friendly, which standard DNA labs are not.

So the blog offer to test solely for FMO3 is almost obsolete, and so no longer offered.


Does Genos fully sequence FMO3 gene ?

At the moment it is not clear, but hoped this will become clear over the next few months

Note : possible 'wild west' way of testing FMO3
Use an ancestry dna site and rummage through the raw data

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